No lymphokines in T-cells around loosened hip prostheses
نویسندگان
چکیده
منابع مشابه
Expression of parathyroid hormone related protein in the tissue around loosened hip prostheses.
OBJECTIVE To investigate the eventual presence and cellular source ofparathyroid hormone related protein (PTHrP) in the synovial-like interface membrane from aseptic loosening of total hip replacement (THR). METHODS A polyclonal rabbit antiserum to the amino-terminal peptide of human PTHrP was used to stain 10 interface membrane samples from loose THR and 10 synovial tissue samples from hip o...
متن کاملBMPs in periprosthetic tissues around aseptically loosened total hip implants
BACKGROUND AND PURPOSE Primary and dynamically maintained periprosthetic bone formation is essential for osseointegration of hip implants to host bone. Bone morphogenetic proteins (BMPs) play a role in osteoinductive bone formation. We hypothesized that there is an increased local synthesis of BMPs in the synovial membrane-like interface around aseptically loosened total hip replacement (THR) i...
متن کاملGene therapy and cement injection for restabilization of loosened hip prostheses.
Loosening of orthopedic hip prostheses is an increasing health problem. In elderly patients with comorbidity,revision surgery may lead to high mortality rates. A less invasive surgical technique is therefore required to reduce these patient risks. To this end a percutaneous gene therapy approach was designed to destroy the periprosthetic loosening membrane, and enable refixing of the hip prosth...
متن کاملMetal sensitivity causing loosened joint prostheses.
Metal sensitivity, as measured by an in-vitro assay on peripheral blood lymphocytes, was evaluated in patients with failed joint prostheses. Lymphocyte transformation to chromium, cobalt, and nickel was measured in 24 patients having revision surgery for a painful or loose prosthesis and compared with that in 11 patients who had a successful hip prothesis in situ for at least 2 years previously...
متن کاملArthrography in loosened hip prostheses. Assessment of possibilities for intra-articular therapy.
BACKGROUND Loosening is a major complication in prosthesis surgery. Less invasive alternatives to revision surgery are required to prevent and treat prosthesis loosening. Some experimental therapies investigating alternative treatments exploit the intra-articular space as a route of administration. For efficient, local delivery of therapeutic agents a contained joint space is required. Furtherm...
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ژورنال
عنوان ژورنال: Acta Orthopaedica Scandinavica
سال: 2001
ISSN: 0001-6470
DOI: 10.1080/00016470152846556